Human IL-18 Matched Antibody Pairs
DescriptionEach Module Set is sufficient for ten 96-well microtiter plates and are identical to eBioscience high quality ready-to-use Conventional ELISAs
Formerly called interferon gamma inducing factor (IGIF), IL-18 is a cytokine that plays an important role in the Th1 response, primarily by its ability to induce IFN gamma production in T cells and natural killer cells.
In terms of structure, IL-18 and IL-1 beta share primary amino acid sequences of the so-called "signature sequence" motif and are similarly folded as all beta pleated sheet molecules. Also similar to IL-1 beta, IL- 18 is synthesized as a biologically inactive precursor molecule lacking a signal peptide which requires cleavage into an active, mature molecule by the intracellular cysteine protease called IL-1 beta-converting enzyme (ICE, caspase-1). The activity of the mature IL-18 is closely related to that of IL-1.
The activity of IL-18 is via an IL-18 receptor complex. IL-18 induces gene expression and synthesis of TNF, IL-1, Fas Ligand, and several chemokines. Similar to IL-1, IL-18 participates in both innate and acquired immunity.
|Components||1 vial (1.1 ml) monoclonal Coating Antibody to human IL-18 (100 ug/ml)
1 vial (55 ul) Biotin-Conjugate anti-human IL-18 monoclonal antibody
1 vial (22 ul) Streptavidin-HRP
1 vial human IL-18 Standard protein lyophilized, 100 ng/ml upon reconstitution
2 vials (50 ml) Sample Diluent
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